Half Life

Read or download online Half Life ebook full in format Pdf, ePub, Kindle, and many more. Half Life written by Krista Foss, published by McClelland & Stewart on 2021-03-02 with 320 pages for you to read. Half Life is one from many Fiction books that available for free in the amazon kindle unlimited, click Get Book to start reading and download books online free now. With Kindle Unlimited Free trial, you can read as many books as you want today.

Half Life

Half Life

  • Author : Krista Foss
  • ISBN :
  • Category : Fiction
  • Publisher : McClelland & Stewart
  • Pages : 320
  • Release Date : 2021-03-02

A raw, absorbing, tender, and witty novel about a woman's long-overdue reckoning with memory, truth, and the multiverse of familial love. Elin Henriksen is a middle-aged single parent under pressure. Her formidable mother's health is declining, her fearless teenage daughter wants to leave but won't say where, and the new high school principal has problems with her unorthodox teaching of physics. And then there is the upcoming ceremony at the Art Museum. In ten days, a gallery will be named after her late father, Tig Henriksen, a modernist furniture designer whose sought-after cult pieces hide a troubled narrative. With a mixture of anticipation and dread, Elin prepares to reunite with her once-estranged siblings--Mette, a free-spirited singer-songwriter, and the serious, emotionally distant architect Casper--hoping they'll finally grapple with hard truths they've so far refused to accept. In the countdown to the event, as her daughter's risk-taking mounts, her mother's fragility intensifies and strange packages land on her doorstep (including a yellow-eyed dog), Elin's only relief is confiding to a dead physicist. Struggling with the paradoxes of truth and clarity, love and witness, genius and ambition, and her own ambivalent connection to her confessor, she inches toward confronting not just the explosive potential of memory but the costly fallout of silence. Told with dazzling insight, intelligence, and compassion, Half Life is a beautifully rendered story about family truths and the profound human need to be believed.

“A smart and unusual romance just about right for fans of John Green.” —Booklist Liana’s decided to boycott kissing this summer, hoping to lose her reputation and focus on planetary science. Hank has near-encyclopedic knowledge of music and Asperger’s syndrome. When they meet by chance in a hospital restroom, neither one realizes that their friendship will change everything. If Liana’s experiment goes as planned, she’ll learn to open up, using her mouth for talking instead of kissing. But Hank’s never been kissed and thinks Liana might be the one to show him . . . if he can stop spewing music trivia long enough to let her.

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I've learned that surviving isn't all it's cracked up to be. NOW: Icie's parents gave her $10,000 in cash, a map of a top-secret bunker, and instructions to get there by any means necessary. They have news of an imminent viral attack and know that the bunker is Icie's only hope for survival. She and three other teens live locked away for months, not knowing what's happening in the outside world or who has survived. Then one day, Icie discovers a shocking secret deep in the bunker. Are they really safe there after all? THEN: Generations in the future, the world has changed, and a mysterious cult worships the very mountain where Icie's secret bunker was built. The people never leave the mountain, they're ruled by Beckett, a teenager...and they have surprising ties to Icie. Icie and Beckett must both fight to survive while protecting a secret that could destroy their civilizations. This high-stakes, original, and thought-provoking adventure follows two unlikely heroes, hundreds of years apart.

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The USA Today bestselling author of In Another Time reimagines the pioneering, passionate life of Marie Curie using a parallel structure to create two alternative timelines, one that mirrors her real life, one that explores the consequences for Marie and for science if she’d made a different choice. In Poland in 1891, Marie Curie (then Marya Sklodowska) was engaged to a budding mathematician, Kazimierz Zorawski. But when his mother insisted she was too poor and not good enough, he broke off the engagement. A heartbroken Marya left Poland for Paris, where she would attend the Sorbonne to study chemistry and physics. Eventually Marie Curie would go on to change the course of science forever and be the first woman to win a Nobel Prize.But what if she had made a different choice? What if she had stayed in Poland, married Kazimierz at the age of twenty-four, and never attended the Sorbonne or discovered radium? What if she had chosen a life of domesticity with a constant hunger for knowledge in Russian Poland where education for women was restricted, instead of studying science in Paris and meeting Pierre Curie? Entwining Marie Curie’s real story with Marya Zorawska’s fictional one, Half Life explores loves lost and destinies unfulfilled—and probes issues of loyalty and identity, gender and class, motherhood and sisterhood, fame and anonymity, scholarship and knowledge. Through parallel contrasting versions of Marya’s life, Jillian Cantor’s unique historical novel asks what would have happened if a great scientific mind was denied opportunity and access to education. It examines how the lives of one remarkable woman and the people she loved – as well as the world at large and course of science and history—might have been irrevocably changed in ways both great and small.

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When Cookie Figowitz, the cook for a party of volatile fur trappers trekking through the Oregon Territory in the 1820s, joins up with the refugee Henry Brown, the two begin a wild ride that takes them from the virgin territory of the West all the way to China and back again. One hundred and sixty years later, Tina Plank, an unhappy teenager, meets Trixie, a girl with a troubled past, and the two become fast friends. But when two skeletons are accidentally unearthed from their common ground, the lives of Tina and Trixie, Cookie and Henry are brought together in unexpected and startling ways. Jonathan Raymond attended Swarthmore College. He was an editor at Plazm magazine and received his M.F.A. from New School University. He currently lives in Brooklyn, New York. "A marvelous novel...a mystery as rich as the history of the Oregon territory itself."-Vanity Fair "Raymond nimbly interweaves these parallel tales and manages to surprise...[a] subtle portrait of friendship and loss...[from] an astute, patient observer."-Entertainment Weekly "Raymond's debut novel teems with carefully researched period details, intrigue...yet it never feels overstuffed."-Washington Post "With The Half-Life, [Raymond] has come home prospecting for literary gold ...Oregon has given him something back."-San Francisco Chronicle "Quietly stunning...Raymond is a kind of stealth bomber of the epic."-Newsday "Terrific...The Half-Life gazes upon those fierce but ephemeral attachments that evade the history books. Multiple plots elegantly veer across the sprawling terrain."-Village Voice

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The fascinating, curious, and sometimes macabre history of radium as seen in its uses in everyday life. Of all the radioactive elements discovered at the end of the nineteenth century, it was radium that became the focus of both public fascination and entrepreneurial zeal. Half Lives tells the fascinating, curious, sometimes macabre story of the element through its ascendance as a desirable item – a present for a queen, a prize in a treasure hunt, a glow-in- the-dark dance costume – to its role as a supposed cure-all in everyday twentieth-century life, when medical practitioners and business people (reputable and otherwise) devised ingenious ways of commodifying the new wonder element, and enthusiastic customers welcomed their radioactive wares into their homes. Lucy Jane Santos—herself the proud owner of a formidable collection of radium beauty treatments—delves into the stories of these products and details the gradual downfall and discredit of the radium industry through the eyes of the people who bought, sold and eventually came to fear the once-fetishized substance. Half Lives is a new history of radium as part of a unique examination of the interplay between science and popular culture.

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It was at the height of the Cold War, in the summer of 1950, when Bruno Pontecorvo mysteriously vanished behind the Iron Curtain. Who was he, and what caused him to disappear? Was he simply a physicist, or also a spy and communist radical? A protégé of Enrico Fermi, Pontecorvo was one of the most promising nuclear physicists in the world. He spent years hunting for the Higgs boson of his day—the neutrino—a nearly massless particle thought to be essential to the process of particle decay. His work on the Manhattan Project helped to usher in the nuclear age, and confirmed his reputation as a brilliant physicist. Why, then, would he disappear as he stood on the cusp of true greatness, perhaps even the Nobel Prize? In Half-Life, physicist and historian Frank Close offers a heretofore untold history of Pontecorvo’s life, based on unprecedented access to Pontecorvo’s friends and family and the Russian scientists with whom he would later work. Close takes a microscope to Pontecorvo’s life, combining a thorough biography of one of the most important scientsts of the twentieth century with the drama of Cold War espionage. With all the elements of a Cold War thriller—classified atomic research, an infamous double agent, a possible kidnapping by Soviet operatives—Half-Life is a history of nuclear physics at perhaps its most powerful: when it created the bomb.physics at perhaps its most powerful: when it created the bomb.

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Lucid narratives of family dramas, global warming, and conversations with Death make a riveting new collection from this prize-winning poet. The poems swing between Mexico City, New York, the Peloponnese, a Staffordshire village and home - their engagement with the church, art and natural beauty provide sure-footed travelling companions.

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When two vagrants meet on the streets of Muncie, Indiana, they are both unaware that their paths crossed years before. Chic, crude and uneducated, is convinced that Sam is nothing more than a harmless lunatic, and Sam, emotionally scarred and psychologically traumatized by events long past, regards Chic as just another denizen of the street. But Chic has spent his adult life trying to purge his soul of the brutal crime he committed as a teenager―the same botched burglary that resulted in the deaths of Sam’s wife and son. Meanwhile, Sam’s daughter Claire is still unable to give up hope that her father might someday reappear. When these three lives converge, the puzzle of the past gradually falls together, but redemption commands a high price, and what is revealed will test the limits of love and challenge the human capacity for forgiveness.

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From the winner of the 1989 National Book Award (for Spartina), a major new novel--wise, sad, and richly comic--about the meltdown of a marriage against the backdrop of a gloriously awful congressional campaign. Charlottesville, Virginia, 1978: Mike is a successful forty-something lawyer, a onetime congressional staffer who's had it with Washington; Joss, his wife, is a filmmaker. They're Virginia liberals with a clan of close-knit friends--a bright, edgy, flirty, games-playing group, spinning like a Catherine wheel around Mike and Joss. But the sparks that fly between the two are getting hotter and more dangerous, as Joss' restlessness turns to impatience and then anger. When one of the group introduces them all to the woman he wants to marry, things suddenly explode--this new arrival and Joss fall passionately in love, and their whole world careens out of control. What ensues is tragicomedy, as Mike tries to allay his rage and misery by letting himself get sucked into a trial run for a seat in Congress. He wants to be a hero to someone; instead he becomes the unwitting star of a political farce. Meantime, Joss is struggling with her new life, and their two young daughters (who form a lovingly unmerciful Greek chorus commenting on the action) have to navigate a turmoil in which one parent is a public joke and the other a private scandal. Rarely has the undoing of love been chronicled with such large-hearted humanity.

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Life is certainly circular. In time, we face the same struggles, reenter the same habitual cycles, and encounter the same types of frustrating people. In time, we always end up facing what we tried our darndest to evade. In fact, we spend so much time trying to avoid the inevitable that we rarely take time to learn, grow, and embrace the rough stuff. Half Life / Die Already suggests that the route to real living is dying to self. With non-stop humor and out-there insights, Mark chronicles his journey-in-progress with often hilarious results. Readers of all ages will enjoy his wit and wisdom, and be inspired to just die already.

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New insights from the science of science Facts change all the time. Smoking has gone from doctor recommended to deadly. We used to think the Earth was the center of the universe and that the brontosaurus was a real dinosaur. In short, what we know about the world is constantly changing. Samuel Arbesman shows us how knowledge in most fields evolves systematically and predictably, and how this evolution unfolds in a fascinating way that can have a powerful impact on our lives. He takes us through a wide variety of fields, including those that change quickly, over the course of a few years, or over the span of centuries.

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A high school boy decides to experiment with drugs, but in doing so transforms his life into a macabre nightmare of bloodshed and madness. While confronted by his familys dark past, he strives to unearth an unknown evil, but risks losing his sanity.

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In this powerful, unforgettable memoir, acclaimed novelist Darin Strauss examines the far-reaching consequences of the tragic moment that has shadowed his whole life. In his last month of high school, he was behind the wheel of his dad's Oldsmobile, driving with friends, heading off to play mini-golf. Then: a classmate swerved in front of his car. The collision resulted in her death. With piercing insight and stark prose, Darin Strauss leads us on a deeply personal, immediate, and emotional journey—graduating high school, going away to college, starting his writing career, falling in love with his future wife, becoming a father. Along the way, he takes a hard look at loss and guilt, maturity and accountability, hope and, at last, acceptance. The result is a staggering, uplifting tour de force. Look for special features inside, including an interview with Colum McCann.

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“Ingenious, sensual, gleeful. . . . It demands of its readers only imagination, and rewards them with hilarity, terror, and marvels.”—Jonathan Lethem, author of Motherless Brooklyn Nora and Blanche are cojoined twins. Nora, the dominant twin, thirsts for love and adventure, while Blanche has been asleep for nearly 30 years. Determined to shed herself of her her sister’s dead weight, Nora leaves for London in search of the mysterious Unity Foundation, which promises to make two one. But once Nora arrives in London, the past begins to surface, forcing her into a most reluctant voyage into memory—a search for meaning and understanding, that will push Nora to the brink of insanity. Grotesque, funny, and dazzlingly told, Shelley Jackson’s first novel is an imaginative and touching portrait of two lives in a cleft world yearning for wholeness.

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One of the finest living writers in the English language, V. S. Naipaul gives us a tale as wholly unexpected as it is affecting, his first novel since the exultantly acclaimed A Way in the World, published seven years ago. Half a Life is the story of Willie Chandran, whose father, heeding the call of Mahatma Gandhi, turned his back on his brahmin heritage and married a woman of low caste—a disastrous union he would live to regret, as he would the children that issued from it. When Willie reaches manhood, his flight from the travails of his mixed birth takes him from India to London, where, in the shabby haunts of immigrants and literary bohemians of the 1950s, he contrives a new identity. This is what happens as he tries to defeat self-doubt in sexual adventures and in the struggle to become a writer—strivings that bring him to the brink of exhaustion, from which he is rescued, to his amazement, only by the love of a good woman. And this is what happens when he returns with her—carried along, really—to her home in Africa, to live, until the last doomed days of colonialism, yet another life not his own. In a luminous narrative that takes us across three continents, Naipaul explores his great theme of inheritance with an intimacy and directness unsurpassed in his extraordinary body of work. And even as he lays bare the bitter comical ironies of assumed identities, he gives us a poignant spectacle of the enervation peculiar to a borrowed life. In one man’s determined refusal of what he has been given to be, Naipaul reveals the way of all our experience. As Willie comes to see, “Everything goes on a bias. The world should stop, but it goes on.” A masterpiece of economy and emotional nuance, Half a Life is an indelible feat of the imagination.

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This report from the Committee on Military Nutrition Research reviews the history of caffeine usage, the metabolism of caffeine, and its physiological effects. The effects of caffeine on physical performance, cognitive function and alertness, and alleviation of sleep deprivation impairments are discussed in light of recent scientific literature. The impact of caffeine consumption on various aspects of health, including cardiovascular disease, reproduction, bone mineral density, and fluid homeostasis are reviewed. The behavioral effects of caffeine are also discussed, including the effect of caffeine on reaction to stress, withdrawal effects, and detrimental effects of high intakes. The amounts of caffeine found to enhance vigilance and reaction time consistently are reviewed and recommendations are made with respect to amounts of caffeine appropriate for maintaining alertness of military personnel during field operations. Recommendations are also provided on the need for appropriate labeling of caffeine-containing supplements, and education of military personnel on the use of these supplements. A brief review of some alternatives to caffeine is also provided.

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ZERO SUM GAME Best of Lists: * Best Books of the Month at The Verge, Book Riot, Unbound Worlds, SYFY, & Kirkus * The Mary Sue Book Club Pick * Library Journal Best Debuts of Fall and Winter A blockbuster, near-future science fiction thriller, S.L. Huang's Zero Sum Game introduces a math-genius mercenary who finds herself being manipulated by someone possessing unimaginable power... Cas Russell is good at math. Scary good. The vector calculus blazing through her head lets her smash through armed men twice her size and dodge every bullet in a gunfight, and she'll take any job for the right price. As far as Cas knows, she’s the only person around with a superpower...until she discovers someone with a power even more dangerous than her own. Someone who can reach directly into people’s minds and twist their brains into Moebius strips. Someone intent on becoming the world’s puppet master. Cas should run, like she usually does, but for once she's involved. There’s only one problem... She doesn’t know which of her thoughts are her own anymore. "Fresh and exciting... a great start to an exciting series--and an exciting career." --Boing Boing At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.

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Compiled by internationally recognized experts in trauma critical care,this sourcediscusses the entire gamut of critical care management of the trauma patient and covers several common complications and conditions treated in surgical intensive care units that are not specifically related to trauma. Utilizing evidence-based guidelines where they ex

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Time is never linear and so is the differentiation between past, present and future. Our lives revolve around a vicious giant circle of millions of unanswered questions. Our existence has a connect with everything that we have seen, we are seeing or we will see and even the things that we have never seen. Half-Life is a journey of a quest to find the reality of the world around. The turmoil of time dilation between past, present and future keeps things rolling and gives an ultimate grip to the story. To chase the mysteries revolving around his life, protagonist Rohit steals information from his dreams and executes in reality. This thrilling story has some magical emotional moments for you to rejoice. You will definitely relate to every situation that unfolds.

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Poradnik do Half-Life 2 zawiera kompletny opis przejścia gry, wraz z uwzględnieniem licznych zagadek natury logicznej. Oprócz tego znajdziecie w nim kompletny opis broni oraz przeciwników, jakich napotkacie na swojej drodze. Half-Life 2 – poradnik do gry zawiera poszukiwane przez graczy tematy i lokacje jak m.in. Route Kanal (2) (Solucja) „Follow Freeman!” (2) (Solucja) „Follow Freeman!” (1) (Solucja) Dark Energy (Solucja) Anticitizen One (2) (Solucja) „Follow Freeman!” (4) (Solucja) „Follow Freeman!” (3) (Solucja) Our Benefactors (Solucja) Route Kanal (3) (Solucja) „Follow Freeman!” (5) (Solucja) Informacja o grze Sequel wyśmienitej gry akcji/FPP „Half-Life” z roku 1998. Gracz ponownie wciela się w postać Gordona Freemana (bohatera oryginalnego „Half-Life’a”) i ponownie musi zmierzyć się z obcymi z planety Xen. Gra Half-Life 2, entuzjastycznie przyjęta zarówno przez krytyków, jak i graczy, to przedstawiciel gatunku strzelanin. Tytuł wydany został w Polsce w 2004 roku i dostępny jest na platformach: PC, XBX. Wersja językowa oficjalnie dystrybuowana na terenie kraju to: angielska.

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Avec des millions de joueurs et le culte inépuisable qui lui est voué, le jeu vidéo Half-Life, sorti en 1998, n'a pas fini de faire parler de lui ! Half-Life. Un nom d’origine scientifique connu de millions de joueurs, qui vouent au jeu un culte éternel. Un nom synonyme d’odyssée inoubliable : celle d’un héros en fuite, Gordon Freeman, à travers les couloirs d’un centre de recherche envahi par des hordes d’extraterrestres qu’il sera obligé d’affronter avec les moyens du bord. Un nom associé à un autre : celui de Valve, studio surdoué dont le mythe s’est forgé précisément avec Half-Life. Un nom qui a redéfini tout un genre, le FPS, auquel il aura permis d’accéder enfin à la maturité, de la plus belle des manières. Derrière ce jeu inoubliable se cache le studio Valve, qui ont construit le mythe avec la création d'Half-Life. Un décryptage complet du phénomène Half-Life, de sa conception à ses retombées, qui parlera à tous les amateurs de gaming ! EXTRAIT 2004 Je fais mes premiers pas chez Arkane Studios. On n’est pas plus de quinze personnes ! Lors de l’entretien d’embauche, je leur demande s’ils développent toujours leur moteur en interne : « On a mieux que ça. Les gens de chez Valve sont fans d’Arx Fatalis, et ils nous offrent leur moteur Source, avec le support ! » Je me mets à décortiquer des niveaux de Half-Life 2, en avant-première mondiale, pour comprendre comment ces gars-là bossent. Je passe des heures à me balader dans Cité 17, à écouter le son du vent dans les rues, scrutant les textures, à me demander comment quelqu’un a pu entremêler de façon si crédible science-fiction et monde contemporain chargé d’histoire. Et aussi bien donner naissance à cette illusion de vie, créer de l’empathie pour les personnages, alliés ou ennemis, me procurer autant de plaisir à jouer, tout en me laissant le contrôle total. Je joue aux jeux vidéo depuis tout petit. Depuis mon premier ordinateur, un TI-99. Je me suis ensuite procuré toutes les générations de consoles. J’ai vu de superbes jeux, qui m’ont donné un plaisir fou, mais il faut que je l’avoue : Half-Life 2 a été une étape significative dans ma vie, un tournant, même. Il m’a fait comprendre l’importance des mondes qu’on crée à partir de rien, et de l’imbrication entre gameplay, musique, histoire, technologie et design. CE QU'EN PENSE LA CRITIQUE À lire absolument si vous vous intéressez de près ou de loin aux jeux vidéos, à la science-fiction d'anticipation ou à ce véritable phénomène culturel. - Godefroy Vandepoele, Sens critique Très bien écrit, jamais ennuyant, « Half-Life : le FPS libéré » est un excellent livre qui parvient surtout à rappeler aux joueurs pourquoi Half-Life et sa suite sont des jeux si marquants [...] C’est un livre passionnant et sans aucun doute, l’un des meilleurs actuellement disponible sur le marché. - Skywilly, gamesidestory.com

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An intricately woven debut psychological mystery and a profound coming of age story for fans of Made You Up by Francesca Zappia and All the Bright Places by Jennifer Niven. “Introduces a fierce new presence.” —Publishers Weekly (starred review) “5 out of 5 bright, beautiful stars.” —Teenreads.com “A fascinating debut...something original indeed. Readers will absolutely need to know the end of this unique inward-facing mystery.” —ALA Booklist For all of her seventeen years, Molly feels like she’s missed bits and pieces of her life. Her memory is perforated with holes and gaps. But then a horrible accident changes everything. Now she’s starting to remember her own disturbing secrets. And bit by bit, Molly uncovers the separate life she seems to have led—and the love that she can’t let go.

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This book begins with the basic terms and definitions and takes a student, step by step, through all areas of medical physics. The book covers radiation therapy, diagnostic radiology, dosimetry, radiation shielding, and nuclear medicine, all at a level suitable for undergraduates. This title not only describes the basics concepts of the field, but also emphasizes numerical and mathematical problems and examples. Students will find An Introduction to Medical Physics to be an indispensible resource in preparations for further graduate studies in the field.

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This volume discusses the background and various clinical applications of radiation therapy in the treatment of non-malignant diseases. It documents the radiobiological and physical principles of treatment and the rationale underlying the use of radiotherapy for various disorders of the CNS, head and neck, eye, skin and soft tissues, bone and joints, and vascular system. In so doing, it draws attention to and elucidates the scope for application of radiotherapy beyond the treatment of malignancies. Both the risks and the benefits of such treatment are fully considered, the former ranging from minor clinical problems to life-threatening diseases.

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A recipient of the PROSE 2017 Honorable Mention in Chemistry & Physics, Radioactivity: Introduction and History, From the Quantum to Quarks, Second Edition provides a greatly expanded overview of radioactivity from natural and artificial sources on earth, radiation of cosmic origins, and an introduction to the atom and its nucleus. The book also includes historical accounts of the lives, works, and major achievements of many famous pioneers and Nobel Laureates from 1895 to the present. These leaders in the field have contributed to our knowledge of the science of the atom, its nucleus, nuclear decay, and subatomic particles that are part of our current knowledge of the structure of matter, including the role of quarks, leptons, and the bosons (force carriers). Users will find a completely revised and greatly expanded text that includes all new material that further describes the significant historical events on the topic dating from the 1950s to the present. Provides a detailed account of nuclear radiation – its origin and properties, the atom, its nucleus, and subatomic particles including quarks, leptons, and force carriers (bosons) Includes fascinating biographies of the pioneers in the field, including captivating anecdotes and insights Presents meticulous accounts of experiments and calculations used by pioneers to confirm their findings

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Section-I: Solid State Physics| Section-Ii Electronics | Section-Iii: Nuclear And Particle Physics

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Based on an American Chemical Society Symposium organized by Professors Glenn Seaborg and Oliver Manuel, this volume provides a comprehensive record of different views on this important subject at the end of the 20th century. They have assembled a blend of highly respected experimentalists and theorists from astronomy, geology, meteoritics, planetology and nuclear chemistry and physics to discuss the origin of elements in the solar system. The intent was to include all points of view and let history judge their validity.

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Papers: characterization of inducible nitric oxide synthase expression in human airway epithelium; nitric oxide and its congeners in mitochondria; role of nitric oxide in inflammation and tissue injury during endotoxemia and hemorrhagic shock; nitric oxide and peroxynitrite production in ocular inflammation; 5 papers on pulmonary/pollutant effects; 6 papers on oxidants and signal transduction, including impact of oxidative stress on signal transduction control by phosphotyrosine phosphatases; the nature of antioxidant defense mechanisms; lipid peroxidation products and antioxidants in human disease; and lung injury and oxidoreductases.

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This accessible, easy-to-read book provides readers with different perspectives on the subject of painkillers, examining their history, production, uses, and dangers. • Documents the risks of painkiller use and explores the various issues centered around the production, distribution, and regulation of painkiller medications • Examines painkillers from a variety of perspectives, including medical, historical, economic, and social • Includes primary source documents such as guidelines, policy documents, and study findings on the topics covered that provide readers with more in-depth information and help students hone their critical thinking and analytical skills • Examines the social dimensions of the use and abuse of painkiller drugs and considers the future of this particular type of drugs

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Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out ... and also for use as a reference book ...." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD .... “ (British Toxicology Society Newsletter)

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This two-volume set provides essential information on the general princi-ples of target organ toxicity. Pharmacokinetics, metabolic activation and key defense mechanisms, excretion, species variation, and tissue-specific biochemistry are explored comprehensively. These general principles are then illustrated using specific examples of toxicity to different target organs and systems. DNA modifi-cation and repair in tumor induction, and specificity in tumor initiation are also examined. Of primary interest to toxicologist, pharma-cologists, biochemists, and environmental toxicologists.

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First published in 1998. Routledge is an imprint of Taylor & Francis, an informa company.

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In about two hundred years, the human race on Earth is perhaps facing extinction due to the rapid evolution of disease. A crew of young men and women travel to the moons of Saturn, to Titan, to investigate the biochemistry of the pre-life conditions there in the slim hope of discovering something that might save Earth. The whole story runs at high-speed, as they race to find answers across the surface of an alien landscape with death close behind . . . and gaining. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.

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The Advances in Inorganic Chemistry series present timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bio-inorganic to solid state studies. This acclaimed serial features reviews written by experts in the field and serves as an indispensable reference to advanced researchers. Each volume contains an index, and each chapter is fully referenced. * Features comprehensive reviews on the latest developments * Includes contributions from leading experts in the field * Serves as an indispensable reference to advanced researchers

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. . . human kind cannot bear very much reality. T. S. ELIOT, Four Quartets When I was a little child, I lived in an old and somewhat rickety house by the sea. When the winter wind blew, the house would shake and tremble, and cold drafts would whistle through cracks in the walls. You might have thought that lying in bed in a dark room on such cold, windy nights would have frightened me. But it had just the opposite effect: having known this en vironment since birth, I actually found the shaking of the house, the whistling of the wind, and the crashing of the sea to be comforting, and I was lulled to sleep by these familiar sounds. They signaled to me that all was right with the world and that the forces of nature were operating in the normal way. But I did have a problem. On the dimly lit landing of the staircase leading up to my bedroom, there was a large and dark picture of a male lion, sitting as such lions do with his massive paws in front of him and his head erect, turned slightly to the right, and staring straight out at you with yellow blazing eyes. I had great difficulty getting past that lion. Someone would have to hold my hand and take me up to bed, past the dreaded picture.

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This handbook gives a complete and concise description of the up-to-date knowledge of nuclear and radiochemsitry and applications in the various fields of science. I is based on teaching courses and on research for over 40 years. The book is addressed to any researcher whishing sound knowledge about the properties of matter, be it a chemist, a physicist, a medical doctor, a mineralogist or a biologist. They will all find it a valuable source of information about the principles and applications of nuclear and radiochemistry. Research in radiochemistry includes: Study of radioactice matter in nature, investigation of radioactive transmutations by chemical methods, chemistry of radioelements etc. Applications include: Radionuclides in geo- and cosmochemistry, dating by nuclear methods, radioanalysis, Mössbaur spectroscopy and related methods, behaviour of natural and man-made radionuclides in the environment, dosimetry and radiation protection. All subjects are presented clearly and comprehensibly, and in logical sequence. Detailed derivations of equations are avoided and relevant information is compiled in tables. The recent edition of the multi-coloured Karlsruhe 'Chart of the Nuclides' is included. Clearly a standard work by an author with extensive experience in research and teaching.

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With every chapter revised and updated, Physics for Diagnostic Radiology, Third Edition continues to emphasise the importance of physics education as a critical component of radiology training. This bestselling text helps readers understand how various imaging techniques work, from planar analogue and digital radiology to computed tomography (CT),

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